Composition of early life leukocyte populations in preterm infants with and without late-onset sepsis.

ABSTRACT:

Background

Composition of leukocyte populations in the first month of life remains incompletely characterised, particularly in preterm infants who go on to develop late-onset sepsis (LOS).

Aim

To characterise and compare leukocyte populations in preterm infants with and without LOS during the first month of life.

Study design

Single-centre prospective observational cohort study.

Participants

Infants born <30 weeks gestational age (GA).

Outcome measures

Peripheral blood samples were collected at 1, 7, 14, 21 and 28 days of life. Leukocyte populations were characterised using 5-fluorophore-6-marker flow cytometry. Absolute leukocyte counts and frequency of total CD45+ leukocytes of each population were adjusted for GA, birth weight z-scores, sex and total

SUBMITTER: Hibbert J 

PROVIDER: S-EPMC8890632 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature