Ontology highlight
ABSTRACT:
SUBMITTER: Nash AM
PROVIDER: S-EPMC8890714 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Nash Amanda M AM Jarvis Maria I MI Aghlara-Fotovat Samira S Mukherjee Sudip S Hernandez Andrea A Hecht Andrew D AD Rios Peter D PD Ghani Sofia S Joshi Ira I Isa Douglas D Cui Yufei Y Nouraein Shirin S Lee Jared Z JZ Xu Chunyu C Zhang David Y DY Sheth Rahul A RA Peng Weiyi W Oberholzer Jose J Igoshin Oleg A OA Jazaeri Amir A AA Veiseh Omid O
Science advances 20220302 9
Proinflammatory cytokines have been approved by the Food and Drug Administration for the treatment of metastatic melanoma and renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic side effects that limit long-term benefits. To overcome these limitations, we developed a clinically translatable cytokine delivery platform composed of polymer-encapsulated human ARPE-19 (RPE) cells that produce natural cytokines. Tumor ...[more]