Mice alternate between discrete strategies during perceptual decision-making.

ABSTRACT: Classical models of perceptual decision-making assume that subjects use a single, consistent strategy to form decisions, or that decision-making strategies evolve slowly over time. Here we present new analyses suggesting that this common view is incorrect. We analyzed data from mouse and human decision-making experiments and found that choice behavior relies on an interplay among multiple interleaved strategies. These strategies, characterized by states in a hidden Markov model, persist for tens to hundreds of trials before switching, and often switch multiple times within a session. The identified decision-making strategies were highly consistent across mice and comprised a single 'engaged' state, in which decisions relied heavily on the sensory stimulus, and several biased states in whic

SUBMITTER: Ashwood ZC 

PROVIDER: S-EPMC8890994 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature