Inherited TP53 Variants and Risk of Prostate Cancer.

ABSTRACT:

Background

Inherited germline TP53 pathogenic and likely pathogenic variants (gTP53) cause autosomal dominant multicancer predisposition including Li-Fraumeni syndrome (LFS). However, there is no known association of prostate cancer with gTP53.

Objective

To determine whether gTP53 predisposes to prostate cancer.

Design, setting, and participants

This multi-institutional retrospective study characterizes prostate cancer incidence in a cohort of LFS males and gTP53 prevalence in a prostate cancer cohort.

Outcome measurements and statistical analysis

We evaluated the spectrum of gTP53 variants and clinical features associated with prostate cancer.

Results and limitations

We identified 31 prostate cancer cases among 163 adult LFS males, including 26 of 54 ag

SUBMITTER: Maxwell KN 

PROVIDER: S-EPMC8891030 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature