Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory ¹¹ C-UCB-J positron emission tomography study in humans.

ABSTRACT: Preclinical studies have revealed robust and long-lasting alterations in dendritic spines in the brain following cocaine exposure. Such alterations are hypothesized to underlie enduring maladaptive behaviours observed in cocaine use disorder (CUD). The current study explored whether synaptic density is altered in CUD. Fifteen individuals with DSM-5 CUD and 15 demographically matched healthy control (HC) subjects participated in a single ¹¹ C-UCB-J positron emission tomography scan to assess density of synaptic vesicle glycoprotein 2A (SV2A). The volume of distribution (V_T ) and the plasma-free fraction-corrected form of the total volume of distribution (V_T /f_P ) were analysed in the anterior cingulate cortex (ACC), dorsomedial and ventromedial pr

SUBMITTER: Angarita GA 

PROVIDER: S-EPMC8891080 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature