Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas.

ABSTRACT:

Opinion statement

Advances in proteomic and metabolomic technologies have accelerated our understanding of multiple aspects of cancer biology across distinct tumour types. Here we review the current state-of-the-art in the use of proteomics and metabolomics in soft tissue sarcomas. We highlight the utility of these Omics-based methodologies to identify new drug targets, synthetic lethal interactions, candidate therapeutics and novel biomarkers to facilitate patient stratification. Due to the unbiased and global nature of these profiling methods to assess the levels of protein expression, post-translational modifications such as phosphorylation and glycosylation as well as key metabolites, many of these findings have broad applications not just in specific histotypes but across mult

SUBMITTER: Chadha M 

PROVIDER: S-EPMC8891095 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature