Metabolomics changes in brain-gut axis after unpredictable chronic mild stress.

ABSTRACT:

Background

Major depressive disorder is a leading cause of disability worldwide, affecting up to 17 % of the general population. The neural mechanisms of depression, however, are yet to be uncovered. Recently, attention has been drawn to the effects of dysfunctional brain-gut axis on depression, and many substances have been suggested to be involved in the communication between the gut and brain, such as ghrelin.

Methods

We herein systematically examined the changes of metabolomics after unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in rats and compared the altered metabolites in the hippocampus and jejunum samples.

Results

Our results show that many metabolites significantly changed with UCMS both in the hippocampus and jejunum, such as L

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8891102 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature