MDMA and memory, addiction, and depression: dose-effect analysis.

ABSTRACT:

Rationale

±3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug that shows substantial promise as a psychotherapeutic agent. Still, there is some concern regarding its behavioral toxicity, and its dose-effect relationship is poorly understood. We previously explored the role of dose in the cognitive effects of MDMA in a systematic review of existing literature and found no evidence in animals that MDMA impairs memory at low doses (< 3 mg/kg) but mixed results at high doses (≥ 3 mg/kg). Since this review comprised mostly of single-dose studies and an assortment of methodologies, an empirical dose-ranging study on this topic is warranted.

Objectives

The current study aims to evaluate the conclusion from our systematic review that 3 mg/kg may be the threshold for MDM

SUBMITTER: Pantoni MM 

PROVIDER: S-EPMC8891111 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature