Insights Gained and Future Outlook From scRNAseq Studies in Autoimmune Rheumatic Diseases.

ABSTRACT: Autoimmune rheumatic diseases have a major impact on public health as one of the most common morbidities, and many of these disorders involve both local and systemic manifestations with severe consequences for patient health and quality of life. However, treatment options for many of these diseases remain inadequate for a substantial portion of patients, and progress in developing novel therapeutics has been slow. This lack of progress can be largely attributed to an insufficient understanding of the complex mechanisms driving pathogenesis. Recently, the emergence of single-cell RNA sequencing (scRNAseq) has offered a powerful new tool for interrogating rheumatic diseases, with the potential to assess biological heterogeneity and individual cell function in rheumatic diseases. In this revi

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC8891165 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature