Diet Quality Scores Are Positively Associated with Whole Blood-Derived Mitochondrial DNA Copy Number in the Framingham Heart Study.

ABSTRACT:

Background

The association between diet quality and mitochondrial DNA copy number (mtDNA-CN) remains to be examined.

Objectives

We aimed to study the relation between diet quality and mtDNA-CN.

Methods

We analyzed data from 2931 Framingham Heart Study (FHS) participants (mean age of 57 y, 55% females). Whole-genome sequencing was used to calculate mtDNA-CN from whole-blood samples. We examined the cross-sectional associations between 3 diet quality scores, the Dietary Approaches to Stop Hypertension (DASH) score, the Alternative Healthy Eating Index (AHEI), and the Mediterranean diet score (MDS), and mtDNA-CN. Linear mixed models were used to account for maternal lineage.

Results

We observed that a higher DASH score was positively associated with mtDNA-CN after

SUBMITTER: Ma J 

PROVIDER: S-EPMC8891175 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature