Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury.

ABSTRACT:

Rationale

Infants born prematurely risk developing diffuse white matter injury (WMI), which is associated with impaired cognitive functioning and an increased risk of autism spectrum disorder. Recently, our rat model of preterm diffuse WMI induced by combined fetal inflammation and postnatal hypoxia showed impaired motor performance, anxiety-like behaviour and autism-like behaviour in juvenile rats, especially males. Immunohistochemistry showed delayed myelination in the sensory cortex and impaired oligodendrocyte differentiation.

Objective

To assess long-term cognitive deficits in this double-hit rat model of diffuse WMI, animals were screened on impulsivity, attention and cognitive flexibility in adulthood using the 5-choice serial reaction time task (5CSRTT) and a probabi

SUBMITTER: Achterberg EJM 

PROVIDER: S-EPMC8891199 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature