L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task.

ABSTRACT:

Rationale

The cognitive control dilemma describes the necessity to balance two antagonistic modes of attention: stability and flexibility. Stability refers to goal-directed thought, feeling, or action and flexibility refers to the complementary ability to adapt to an ever-changing environment. Their balance is thought to be maintained by neurotransmitters such as dopamine, most likely in a U-shaped rather than linear manner. However, in humans, studies on the stability-flexibility balance using a dopaminergic agent and/or measurement of brain dopamine are scarce.

Objective

The study aimed to investigate the causal involvement of dopamine in the stability-flexibility balance and the nature of this relationship in humans.

Methods

Distractibility was assessed as the diff

SUBMITTER: Riedel P 

PROVIDER: S-EPMC8891202 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature