Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence.

ABSTRACT:

Objective

Stimulant use instigates abstinence syndrome in humans. miRNAs are a critical component for the pathophysiology of stimulant abstinence. Here we sought to identify a miRNA marker of methamphetamine abstinence in the circulating extracellular vesicles (cEVs).

Methods

miR-137 in the cEVs was quantified by qPCR in thirty-seven patients under methamphetamine abstinence and thirty-five age-matched healthy controls recruited from 2014 to 2016 from the general adult population in a hospital setting, Seoul, South Korea. Diagnostic power was evaluated by area under curve in the receiver-operating characteristics curve and other multiple statistical parameters.

Results

Patients under methamphetamine abstinence exhibited a significant reduction in cEV miR-137. Overall,

SUBMITTER: Kim B 

PROVIDER: S-EPMC8891205 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature