Increased elasticity of sucrose demand during hyperdopaminergic states in rats.

ABSTRACT:

Rationale

Deficits in cost-benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been implicated in various processes related to cognition and reward, but its precise role in reward valuation and cost-benefit trade-off decisions remains incompletely understood.

Objectives

We assessed the role of mesocorticolimbic dopamine signalling in the relationship between price and consumption of sucrose, to better understand its role in cost-benefit decisions.

Methods

Dopamine neurons in the ventral tegmental area (VTA) were chemogenetically activated in rats, and a behavioural economics approach was used to quantify the relationship between pric

SUBMITTER: Minnaard AM 

PROVIDER: S-EPMC8891210 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature