Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection.

ABSTRACT: The COVID19 pandemic has led to multipronged approaches for treatment of the disease. Since de novo discovery of drugs is time consuming, repurposing of molecules is now considered as one of the alternative strategies to treat COVID19. Antibacterial peptides are being recognized as attractive candidates for repurposing to treat viral infections. In this study, we describe the anti-SARS-CoV-2 activity of the well-studied antibacterial peptides gramicidin S and melittin obtained from Bacillus brevis and bee venom respectively. The EC₅₀ values for gramicidin S and melittin were 1.571 µg and 0.656 µg respectively based on in vitro antiviral assay. Significant decrease in the viral load as compared to the untreated group with no/very less cytotoxicity was observed. Both the peptides

SUBMITTER: Enayathullah MG 

PROVIDER: S-EPMC8891299 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature