Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.

ABSTRACT: Brown adipose tissue (BAT) dissipates chemical energy as heat through uncoupling protein 1 (UCP1). The induction of mitochondrial reactive oxygen species (ROS) in BAT was recently identified as a mechanism that supports UCP1-dependent thermogenesis. We previously demonstrated that nardilysin (NRDC) plays critical roles in body temperature homeostasis. Global NRDC-deficient (Nrdc^-/-) mice show hypothermia due to a lower set point for body temperature, whereas BAT thermogenesis at room temperature (RT) is enhanced mainly to compensate for poor thermal insulation. To examine the primary role of NRDC in BAT thermogenesis, we generated adipocyte-specific NRDC-deficient (Adipo-KO) mice by mating Nrdc floxed (Nrdc^flox/flox) mice with adiponectin-Cre mice. Adipo-KO mice showe

SUBMITTER: Saijo S 

PROVIDER: S-EPMC8891301 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature