Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons.

ABSTRACT: Microbial flora is investigated to be related with neuropathological conditions in Alzheimer's disease (AD), and is attracting attention as a drug discovery resource. However, the relevance between the soil microbiota and the pathological condition has not been fully clarified due to the difficulty in isolation culture and the component complexity. In this study, we established a library of secondly metabolites produced in microorganism to investigate the potential effect of microorganisms on the production of amyloid β (Aβ), one of the most representative pathogens of AD. We conducted a library screening to quantify Aβ and neuronal toxicity by using cortical neurons from human induced pluripotent stem cells (iPSCs) of AD patients after adding secondary metabolites. Screening results and f

SUBMITTER: Kondo T 

PROVIDER: S-EPMC8891331 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature