Homotypic targeting of immunomodulatory nanoparticles for enhanced peripheral and central immunity.

ABSTRACT:

Objectives

Synthetic oligodeoxynucleotides (ODNs) that contain unmethylated cytosine-phosphate-guanine (CpG) motifs serve as immune adjuvants in disease treatment. However, the poor cell permeability and safety concerns limit their medical applications, and biocompatible strategies for efficient delivery of functional CpG ODNs are highly desirable.

Materials and methods

Self-assembled, cell membrane-coated CpG nanoparticles (NP) are prepared, and their physicochemical properties are characterized. The uncoated and membrane-coated CpG NP are compared for their biocompatibility, cellular uptake kinetics, endocytic pathways, subcellular localization, and immunostimulatory activities in macrophages and microglia.

Results

Macrophage- or microglia-derived cell membrane camo

SUBMITTER: Shen Y 

PROVIDER: S-EPMC8891550 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature