A multiscale cell-based model of tumor growth for chemotherapy assessment and tumor-targeted therapy through a 3D computational approach.

ABSTRACT:

Objectives

Computational modeling of biological systems is a powerful tool to clarify diverse processes contributing to cancer. The aim is to clarify the complex biochemical and mechanical interactions between cells, the relevance of intracellular signaling pathways in tumor progression and related events to the cancer treatments, which are largely ignored in previous studies.

Materials and methods

A three-dimensional multiscale cell-based model is developed, covering multiple time and spatial scales, including intracellular, cellular, and extracellular processes. The model generates a realistic representation of the processes involved from an implementation of the signaling transduction network.

Results

Considering a benign tumor development, results are in good agre

SUBMITTER: Jafari Nivlouei S 

PROVIDER: S-EPMC8891571 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature