Development and Performance Evaluation of a Novel Ancestry Informative DIP Panel for Continental Origin Inference.

ABSTRACT: Ancestry informative markers (AIMs) are useful to infer individual biogeographical ancestry and to estimate admixture proportions of admixed populations or individuals. Although a growing number of AIM panels for forensic ancestry origin analyses were developed, they may not efficiently infer the ancestry origins of most populations in China. In this study, a set of 52 ancestry informative deletion/insertion polymorphisms (AIDIPs) were selected with the aim of effectively differentiate continental and partial Chinese populations. All of the selected markers were successfully incorporated into a single multiplex PCR panel, which could be conveniently and efficiently detected on capillary electrophoresis platforms. Genetic distributions of the same 50 AIDIPs in different continental populati

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8891605 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature