Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators.

ABSTRACT:

Background & aims

Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs.

Methods

Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK⁺/CD206⁺/CD163⁺/CD209^- macrophages. The role of MerTK was assessed by pharmacologic an

SUBMITTER: Pastore M 

PROVIDER: S-EPMC8891698 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature