Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling.

ABSTRACT: Mulberrin (Mul) is a key component of the traditional Chinese medicine Romulus Mori with various biological functions. However, the effects of Mul on liver fibrosis have not been addressed, and thus were investigated in our present study, as well as the underlying mechanisms. Here, we found that Mul administration significantly ameliorated carbon tetrachloride (CCl₄)-induced liver injury and dysfunction in mice. Furthermore, CCl₄-triggerd collagen deposition and liver fibrosis were remarkably attenuated in mice with Mul supplementation through suppressing transforming growth factor β1 (TGF-β1)/SMAD2/3 signaling pathway. Additionally, Mul treatments strongly restrained the hepatic inflammation in CCl₄-challenged mice via blocking nuclear factor-κB (NF-κB) si

SUBMITTER: Ge C 

PROVIDER: S-EPMC8891817 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature