Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross.

ABSTRACT: Thermal nociception involves the transmission of temperature-related noxious information from the periphery to the CNS and is a heritable trait that could predict transition to persistent pain. Rodent forward genetics complement human studies by controlling genetic complexity and environmental factors, analysis of end point tissue, and validation of variants on appropriate genetic backgrounds. Reduced complexity crosses between nearly identical inbred substrains with robust trait differences can greatly facilitate unbiased discovery of novel genes and variants. We found BALB/cByJ mice showed enhanced sensitivity on the 53.5°C hot plate and mechanical stimulation in the von Frey test compared to BALB/cJ mice and replicated decreased gross brain weight in BALB/cByJ versus BALB/cJ. We then id

SUBMITTER: Beierle JA 

PROVIDER: S-EPMC8891926 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature