Complement 4 Aids in the Prediction of Newly Diagnosed Multiple Myeloma Outcome in Patients.

ABSTRACT:

Background

A cure for the heterogeneous hematological malignancy multiple myeloma (MM) is yet to be developed. To date, the early risk factors associated with poor outcomes in MM have not been fully elucidated. Studies have shown an aberrant complement system in patients with MM, but the precise association necessitates elucidation. Therefore, this study scrutinizes the correlation between serum complement level and the disease outcome of patients with MM.

Methods

A retrospective analysis of 72 patients with MM (new diagnosis) with complement C4 and C3 along with common laboratory indicators was done. The Pearson χ² test and the Mann-Whitney U-test were done to evaluate categorical or binary variables and intergroup variance, respectively. Kaplan-Meier test

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8891941 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature