Predictors of echocardiographic response to cardiac resynchronization therapy: A systematic review with Meta-Analysis.

ABSTRACT:

Background

At least 30% of the patients do not respond to cardiac resynchronization therapy (CRT). We performed a systematic review and meta-analysis of real-world studies trying to identify predictors of response to CRT.

Methods

PubMed, Embase and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for observational prospective studies, referring the evaluation of response to CRT, defined as a decrease in left ventricle end-systolic volume (LVESV) ≥ 15% at 6-month follow-up, via two-dimensional echocardiography.

Results

A total of 24 studies were included. The meta-analysis showed that female gender (p = 0.018), non-ischemic cardiomyopathy (NICM) (p < 0.001), left bundle branch morphology (LBBB) (p = 0.001), longer QRS (p < 0.001) and

SUBMITTER: Martins R 

PROVIDER: S-EPMC8891947 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature