Virome and Blood Meal-Associated Host Responses in Ixodes persulcatus Naturally Fed on Patients.

ABSTRACT: The long-lasting co-evolution of ticks with pathogens results in mutual adaptation. Blood-feeding is one of the critical physiological behaviors that have been associated with the tick microbiome; however, most knowledge was gained through the study of laboratory-reared ticks. Here we detached Ixodes persulcatus ticks at different stages of blood-feeding from human patients and performed high-throughput transcriptomic analysis on them to identify their virome and genes differentially expressed between flat and fully fed ticks. We also traced bloodmeal sources of those ticks and identified bats and three other potential mammalian hosts, highlighting the public health significance. We found Jingmen tick virus and 13 putative new viruses belonging to 11 viral families, three of which e

SUBMITTER: Li LJ 

PROVIDER: S-EPMC8891964 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature