Biochemical clusters predict mortality and reported inability to work 10 ​years later.

ABSTRACT:

Background

Chronic systemic inflammation has been linked to premature mortality and limited somatic as well as mental health with consequences for capability to work and everyday functioning. We recently identified three biochemical clusters of endocrine and immune parameters (C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, cortisol and creatinine) in participants, age 35-81 years, of the open access Midlife in the United States Study (MIDUS) dataset. These clusters have been validated in an independent cohort of Japanese mid-life adults. Among these clusters, the one characterized by high inflammation coupled with low cortisol and creatinine concentrations was associated with the highest disease burden, referred to as high-risk cluster in the following. The current stu

SUBMITTER: Bertele N 

PROVIDER: S-EPMC8892089 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature