Heterotopic ossification vs. fracture healing: Extracellular vesicle cargo proteins shed new light on bone formation.

ABSTRACT: Fibrodysplasia ossificans progressiva (FOP) is an extremely rare disease in which bone tissue forms in extraskeletal sites, which is known as heterotopic ossification (HO). Extracellular vesicles (EVs) are small phospholipid-enclosed particles released by various cells which have an emerging, but not completely understood role in various (patho)physiological processes. In order to further study the pathophysiology of FOP we conducted a small observational study comparing the proteomic profiles of EV cargo, derived from pooled plasma of four patient groups: FOP patient (N = 1) during active disease phase (flare-up), FOP patients during remission (N = 2), patients after long bone fracture (N = 20) and healthy controls (N = 10). After isolation of EVs - their prote

SUBMITTER: Hrkac S 

PROVIDER: S-EPMC8892095 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature