A Novel Thioredoxin-Like Protein of Babesia microti Involved in Parasite Pathogenicity.

ABSTRACT: Babesiosis poses a serious threat to immunocompromised individuals and the major etiological species of Babesia for human babesiosis is Babesia microti. Merozoites are a critical stage in the life cycle of Babesia microti. Several merozoite proteins have been demonstrated to play important roles in this process; however, most of the merozoite proteins of B. microti remain unknown. In the present study, we identified a novel merozoite protein of B. microti with similar structure to the thioredoxin (Trx)-like domain of the Trx family, which was named as B. microti Trx-like protein (BmTLP). Western blot assays demonstrated that this protein was expressed by B. microti during the erythrocytic infection process, and its expression peaked o

SUBMITTER: Piao X 

PROVIDER: S-EPMC8892138 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature