Alterations in Gut Microbiota Are Correlated With Serum Metabolites in Patients With Insomnia Disorder.

ABSTRACT: This study aimed to investigate insomnia-related alterations in gut microbiota and their association with serum metabolites. A total of 24 patients with insomnia disorder and 22 healthy controls were recruited. The fecal and serum samples were collected. The 16s rRNA sequencing and bioinformatics analysis were conducted to explore insomnia-related changes in the diversity, structure, and composition of the gut microbiota. UPLC-MS was performed to identify insomnia-related serum metabolites. Spearman correlation analysis was used to investigate the correlations between insomnia-related gut bacteria and the serum metabolites. Despite the nonsignificant changes in the diversity and structure of gut microbiota, insomnia disorder patients had significantly decreased family Bacteroidaceae

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8892143 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature