2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy.

ABSTRACT: An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities. We report here a dual-therapeutic prodrug, DOXjade, that allows for iron chelation chemo-photothermal cancer therapy. This prodrug takes advantage of the clinically approved iron chelator deferasirox (ExJade®) and the topoisomerase 2 inhibitor, doxorubicin (DOX). Loading DOXjade onto ultrathin 2D Ti₃C₂ MXene nanosheets produces a construct, Ti ₃ C ₂ -PVP@DOXjade, that a

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8892152 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature