The functional insight into the genetics of cardiovascular disease: results from the post-GWAS study.

ABSTRACT: Cardiovascular diseases (CVDs), the leading cause of death worldwide, generally refer to a range of pathological conditions with the involvement of the heart and the blood vessels. A sizable fraction of the susceptibility loci is known, but the underlying mechanisms have been established only for a small proportion. Therefore, there is an increasing need to explore the functional relevance of trait-associated variants and, moreover, to search for novel risk genetic variation. We have reported the bioinformatic approach allowing effective identif ication of functional non-coding variants by integrated analysis of genome-wide data. Here, the analysis of 1361 previously identif ied regulatory SNPs (rSNPs) was performed to provide new insights into cardiovascular risk. We found 773,471 coding

SUBMITTER: Bryzgalov LO 

PROVIDER: S-EPMC8892170 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature