Nucleotide Variation in <i>Drosophila cryptochrome</i> Is Linked to Circadian Clock Function: An Association Analysis.

ABSTRACT: Cryptochrome (CRY) is a conserved protein associated with the circadian clock in a broad range of organisms, including plants, insects, and mammals. In Drosophila, cry is a pleiotropic gene that encodes a blue light-dedicated circadian photoreceptor, as well as an electromagnetic field sensor and a geotaxis behavior regulator. We have generated a panel of nearly-isogenic strains that originated from various wild populations and which carry different natural alleles of cry. Sequencing of these alleles revealed substantial polymorphism, the functional role of which was elusive. To link this natural molecular diversity to gene function, we relied on association mapping. Such analysis revealed two major haplogroups consisting of six linked nucleotides associated with circa

SUBMITTER: Pegoraro M 

PROVIDER: S-EPMC8892179 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature