Cardiovascular Response to Posture Changes: Multiscale Modeling and in vivo Validation During Head-Up Tilt.

ABSTRACT: In spite of cardiovascular system (CVS) response to posture changes have been widely studied, a number of mechanisms and their interplay in regulating central blood pressure and organs perfusion upon orthostatic stress are not yet clear. We propose a novel multiscale 1D-0D mathematical model of the human CVS to investigate the effects of passive (i.e., through head-up tilt without muscular intervention) posture changes. The model includes the main short-term regulation mechanisms and is carefully validated against literature data and in vivo measures here carried out. The model is used to study the transient and steady-state response of the CVS to tilting, the effects of the tilting rate, and the differences between tilt-up and tilt-down. Passive upright tilt led to an increase of m

SUBMITTER: Fois M 

PROVIDER: S-EPMC8892183 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature