Nematode ascarosides attenuate mammalian type 2 inflammatory responses.

ABSTRACT: Mounting evidence suggests that nematode infection can protect against disorders of immune dysregulation. Administration of live parasites or their excretory/secretory (ES) products has shown therapeutic effects across a wide range of animal models for immune disorders, including asthma. Human clinical trials of live parasite ingestion for the treatment of immune disorders have produced promising results, yet concerns persist regarding the ingestion of pathogenic organisms and the immunogenicity of protein components. Despite extensive efforts to define the active components of ES products, no small molecules with immune regulatory activity have been identified from nematodes. Here we show that an evolutionarily conserved family of nematode pheromones called ascarosides strongly modulates

SUBMITTER: Shinoda K 

PROVIDER: S-EPMC8892368 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature