5-methylcytosine modification by <i>Plasmodium</i> NSUN2 stabilizes mRNA and mediates the development of gametocytes.

ABSTRACT: 5-methylcytosine (m⁵C) is an important epitranscriptomic modification involved in messenger RNA (mRNA) stability and translation efficiency in various biological processes. However, it remains unclear if m⁵C modification contributes to the dynamic regulation of the transcriptome during the developmental cycles of Plasmodium parasites. Here, we characterize the landscape of m⁵C mRNA modifications at single nucleotide resolution in the asexual replication stages and gametocyte sexual stages of rodent (Plasmodium yoelii) and human (Plasmodium falciparum) malaria parasites. While different representations of m⁵C-modified mRNAs are associated with the different stages, the abundance of the m⁵C marker is strikingly enhan

SUBMITTER: Liu M 

PROVIDER: S-EPMC8892369 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature