Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection.

ABSTRACT:

Importance

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized nonatherosclerotic cause of acute myocardial infarction enriched among individuals with early-onset myocardial infarction but is of unclear etiology.

Objective

To assess which genes contribute to the development of SCAD.

Design, setting, and participants

To prioritize genes influencing risk for SCAD, whole-exome sequencing was performed among individuals with SCAD in the discovery and replication cohorts from a tertiary care hospital outpatient specialty clinic, and gene set enrichment analyses were also performed for disruptive coding variants. All patients were sequentially enrolled beginning July 2013. Aggregate prevalence of rare disruptive variants for prioritized gene sets was

SUBMITTER: Zekavat SM 

PROVIDER: S-EPMC8892371 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature