CSB-independent, XPC-dependent transcription-coupled repair in <i>Drosophila</i>.

ABSTRACT: Drosophila melanogaster has been extensively used as a model system to study ionizing radiation and chemical-induced mutagenesis, double-strand break repair, and recombination. However, there are only limited studies on nucleotide excision repair in this important model organism. An early study reported that Drosophila lacks the transcription-coupled repair (TCR) form of nucleotide excision repair. This conclusion was seemingly supported by the Drosophila genome sequencing project, which revealed that Drosophila lacks a homolog to CSB, which is known to be required for TCR in mammals and yeasts. However, by using excision repair sequencing (XR-seq) genome-wide repair mapping technology, we recently found that the Drosophila S2 cell line performs TCR compa

SUBMITTER: Deger N 

PROVIDER: S-EPMC8892495 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature