Resting-state functional connectivity associated with gait characteristics in people with Parkinson's disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a movement disorder caused by dysfunction in the basal ganglia (BG). Clinically relevant gait deficits, such as decreased velocity and increased variability, may be caused by underlying neural dysfunction. Reductions in resting-state functional connectivity (rs-FC) between networks have been identified in PD compared to controls; however, the association between gait characteristics and rs-FC of brain networks in people with PD has not yet been explored. The present study aimed to investigate these associations.

Methods

Gait characteristics and rs-FC MRI data were collected for participants with PD (N = 50). Brain networks were identified from a set of seeds representing cortical, subcortical, and cerebellar regions. Gait outcomes wer

SUBMITTER: Horin AP 

PROVIDER: S-EPMC8892595 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature