Lung microbiota predict chronic rejection in healthy lung transplant recipients: a prospective cohort study.

ABSTRACT:

Background

Alterations in the respiratory microbiome are common in chronic lung diseases, correlate with decreased lung function, and have been associated with disease progression. The clinical significance of changes in the respiratory microbiome after lung transplant, specifically those related to development of chronic lung allograft dysfunction (CLAD), are unknown. The aim of this study was to evaluate the effect of lung microbiome characteristics in healthy lung transplant recipients on subsequent CLAD-free survival.

Methods

We prospectively studied a cohort of lung transplant recipients at the University of Michigan (Ann Arbor, MI, USA). We analysed characteristics of the respiratory microbiome in acellular bronchoalveolar lavage fluid (BALF) collected from asymptomati

SUBMITTER: Combs MP 

PROVIDER: S-EPMC8892628 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature