The effects of gestational diabetes mellitus with maternal age between 35 and 40 years on the metabolite profiles of plasma and urine.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance in pregnancy and without a history of diabetes mellitus. While there are limited metabolomic studies involving advanced maternal age in China, we aim to investigate the metabolomic profiling of plasma and urine in pregnancies complicated with GDM aged at 35-40 years at early and late gestation.

Methods

Twenty normal and 20 GDM pregnant participants (≥ 35 years old) were enlisted from the Complex Lipids in Mothers and Babies (CLIMB) study. Maternal plasma and urine collected at the first and third trimester were detected using gas chromatography-mass spectrometry (GC-MS).

Results

One hundred sixty-five metabolites and 192 metabolites were found in plasma and urine respectively. Urin

SUBMITTER: He XL 

PROVIDER: S-EPMC8892719 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature