Natural killer cell-related gene signature predicts malignancy of glioma and the survival of patients.

ABSTRACT:

Background

Natural killer (NK) cells-based therapies are one of the most promising strategies against cancer. The aim of this study is to investigate the natural killer cell related genes and its prognostic value in glioma.

Methods

The Chinese Glioma Genome Atlas (CGGA) was used to develop the natural killer cell-related signature. Risk score was built by multivariate Cox proportional hazards model. A cohort of 326 glioma samples with whole transcriptome expression data from the CGGA database was included for discovery. The Cancer Genome Atlas (TCGA) datasets was used for validation. GO and KEGG were used to reveal the biological process and function associated with the natural killer cell-related signature. We also collected the clinical pathological features of patients wi

SUBMITTER: Li C 

PROVIDER: S-EPMC8892793 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature