Role of raphe magnus 5-HT_1A receptor in increased ventilatory responses induced by intermittent hypoxia in rats.

ABSTRACT:

Background

Intermittent hypoxia induces increased ventilatory responses in a 5-HT-dependent manner. This study aimed to explore that effect of raphe magnus serotonin 1A receptor (5-HT_1A) receptor on the increased ventilatory responses induced by intermittent hypoxia.

Methods

Stereotaxic surgery was performed in adult male rats, and acute and chronic intermittent hypoxia models were established after recovery from surgery. The experimental group received microinjections of 5-HT_1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the raphe magnus nucleus (RMg). Meanwhile, the control group received microinjections of artificial cerebrospinal fluid instead of 8-OH-DPAT. Ventilatory responses were compared among the different groups o

SUBMITTER: Su J 

PROVIDER: S-EPMC8892800 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature