Ontology highlight
ABSTRACT:
SUBMITTER: Hashem HE
PROVIDER: S-EPMC8892849 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Hashem Heba E HE Amr Abd El-Galil E AEE Nossier Eman S ES Anwar Manal M MM Azmy Eman M EM
ACS omega 20220218 8
A new series of benzimidazole, 1,2,4-triazole, and 1,3,5-triazine derivatives were designed and synthesized using a microwave irradiation synthetic approach utilizing 2-phenylacetyl isothiocyanate <b>(1)</b> as a key starting material. All the new analogues were evaluated as anticancer agents against a panel of cancer cell lines utilizing doxorubicin as a standard drug. Most of the tested derivatives exhibited selective cytotoxic activity against MCF-7 and A-549 cancer cell lines. Furthermore, t ...[more]