A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission Events.

ABSTRACT: Identifying linked cases of infection is a critical component of the public health response to viral infectious diseases. In a clinical context, there is a need to make rapid assessments of whether cases of infection have arrived independently onto a ward, or are potentially linked via direct transmission. Viral genome sequence data are of great value in making these assessments, but are often not the only form of data available. Here, we describe A2B-COVID, a method for the rapid identification of potentially linked cases of COVID-19 infection designed for clinical settings. Our method combines knowledge about infection dynamics, data describing the movements of individuals, and evolutionary analysis of genome sequences to assess whether data collected from cases of infection are consiste

SUBMITTER: Illingworth CJR 

PROVIDER: S-EPMC8892943 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature