The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals.

ABSTRACT: The prenatal-to-postnatal transition is a pivotal process in the life cycle whereby an organism shifts from responding to intrauterine cues to undergoing extrauterine stresses with many physiological adaptations. However, the molecular basis underlying the evolutionarily conserved physiological adaptations remains elusive. Here, we analyze the transcriptomes of seven organs across developmental time points from five mammalian species by constructing computational coexpression networks and report a developmental shift of gene expression at the perinatal stage. The low-to-high and high-to-low expressed genes tightly coalesce in the functional categories and gene regulatory pathways that implicate the physiological adaptions during the prenatal-to-postnatal transition, including lipid metabol

SUBMITTER: Hao J 

PROVIDER: S-EPMC8892945 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature