Network analysis of atherosclerotic genes elucidates druggable targets.

ABSTRACT:

Background

Atherosclerosis is one of the major causes of cardiovascular disease. It is characterized by the accumulation of atherosclerotic plaque in arteries under the influence of inflammatory responses, proliferation of smooth muscle cell, accumulation of modified low density lipoprotein. The pathophysiology of atherosclerosis involves the interplay of a number of genes and metabolic pathways. In traditional translation method, only a limited number of genes and pathways can be studied at once. However, the new paradigm of network medicine can be explored to study the interaction of a large array of genes and their functional partners and their connections with the concerned disease pathogenesis. Thus, in our study we employed a branch of network medicine, gene network analysis

SUBMITTER: Banik SK 

PROVIDER: S-EPMC8893053 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature