Multimodality Imaging for Atrial Fibrosis Detection in the Era of Precision Medicine.

ABSTRACT: In recent years, atrial fibrillation (AF) has increasingly become a focus of attention because it represents the most encountered arrhythmia in clinical practice and a major cause of morbidity and mortality. Issues underlying AF have long been debated; nevertheless, electrical, contractile, and structural remodeling is demonstrated to be the pivotal contributor to arrhythmic substrate. Fibrosis is a hallmark of arrhythmogenic structural remodeling, resulting from an accumulation of fibrillar collagen deposits, as a reparative process to replace degenerating myocardium with concomitant reactive fibrosis, which causes interstitial expansion. Although the precise role of fibrosis in AF initiation and maintenance remains to be fully elucidated, a better definition of its extent and distributio

SUBMITTER: Barletta V 

PROVIDER: S-EPMC8893107 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature