GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition.

ABSTRACT:

Background

Aberrant sympathetic nerve activity exacerbates cardiovascular risk in hypertension and diabetes, which are common comorbidities, yet clinically sympathetic nerve activity remains poorly controlled. The hypertensive diabetic state is associated with increased reflex sensitivity and tonic drive from the peripheral chemoreceptors, the cause of which is unknown. We have previously shown hypertension to be critically dependent on the carotid body (CB) input in spontaneously hypertensive rat, a model that also exhibits a number of diabetic traits. CB overstimulation by insulin and leptin has been similarly implicated in the development of increased sympathetic nerve activity in metabolic syndrome and obesity. Thus, we hypothesized that in hypertensive diabetic state (spontane

SUBMITTER: Pauza AG 

PROVIDER: S-EPMC8893134 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature