Waning immune responses against SARS-CoV-2 variants of concern among vaccinees in Hong Kong.

ABSTRACT:

Background

Nearly 4 billion doses of the BNT162b2-mRNA and CoronaVac-inactivated vaccines have been administrated globally, yet different vaccine-induced immunity against SARS-CoV-2 variants of concern (VOCs) remain incompletely investigated.

Methods

We compare the immunogenicity and durability of these two vaccines among fully vaccinated Hong Kong people.

Findings

Standard BNT162b2 and CoronaVac vaccinations were tolerated and induced neutralizing antibody (NAb) (100% and 85.7%) and spike-specific CD4 T cell responses (96.7% and 82.1%), respectively. The geometric mean NAb IC₅₀ and median frequencies of reactive CD4 subsets were consistently lower among CoronaVac-vaccinees than BNT162b2-vaccinees. CoronaVac did not induce measurable levels of nucleocapsid

SUBMITTER: Peng Q 

PROVIDER: S-EPMC8893246 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature